effective microbubble uses

Enhancing Drug Uptake and Efficacy

“In vivo sonoporation-mediated transfer of low-dose BLM and the cdtB gene induced a significant therapeutic effect on human gingival squamous cell carcinomas”
Iwanaga, K., et al 2007

Gene Therapy Transfection

“Ultrasound can deliver DNA directly to the nucleus –  not just the cytoplasm of the cell.”
Duvshani-Eshet et. al. 2006

“as compared to lipofection that requires endocytosis, sonoporation allowed a rapid and direct transfer of naked DNA into the cell cytoplasm”
Sophie Mehier-Humbert et. al.  2005

Electroporation versus Sonoporation for Gene Therapy Transfection

“…experimental results suggest that sonoporation is more effective than electroporation in transfection for one type of primary cells.”
Pepe et al 2004

More effective High Intensity Focused Ultrasound (HIFU)

“…with the use of ultrasound contrast agents (microbubbles), applications of HIFU are expected to become more efficient, safe, and accurate and to produce fewer adverse effects”
Luo, Wen et al 2006

Molecular Imaging

“Uptake of targeted microbubbles  was significantly higher in tumor than in adjacent skeletal muscle tissue”
Willmann, J, 2008