how will microbubbles and ultrasound
aid your medical application?
Microbubbles are a proven means to enhance ultrasound imaging. Four million patients have been injected with contrast agent microbubbles, primarily for cardiology diagnosis.
Sonoporation is the disruption of microbubbles with ultrasound in order to permeabilize cells and dramatically increase drug uptake and efficacy.
Drugs have been combined with microbubbles, administered intravenously, tracked through the bloodstream using imaging ultrasound, and the bubbles disrupted at the region of interest with higher intensity ultrasound in order to release drugs locally.
Drugs may be co-administered with microbubbles or combined through encapsulation or attachment to the bubble shells. Encapsulation can help avoid toxicity issues and/or protect the therapeutic agent until delivery.
Targeting ligands may also be attached to the shell for targeted therapeutics or molecular imaging.
Microbubbles enhance non-drug therapies such as reducing the cycle time required for high intensity focused ultrasound tumour ablation.